JMJD3 Blocking Peptide | Kdm6b blocking peptide

Mouse JMJD3 Antibody (Center) Blocking Peptide

• Gene Names: Kdm6b; Jmjd3; BC038313; mKIAA0346; 1700064E03Rik
• Synonyms: JMJD3; Mouse JMJD3 Antibody (Center) Blocking Peptide; Lysine-specific demethylase 6B; 11411-; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Kdm6b; Jmjd3; Kiaa0346; Kdm6b blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human Mouse JMJD3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 1641

• Cellular Location: Nucleus.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Kdm6b blocking peptide

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.

NCBI and Uniprot Product Information

• NCBI GI #: 81862258
• NCBI GeneID: 216850
• UniProt Accession #: Q5NCY0; Q3UWY9; Q4VC26; Q6ZQD3
• Molecular Weight: 176,355 Da
• NCBI Official Full Name: Lysine-specific demethylase 6B
• NCBI Official Synonym Full Names: KDM1 lysine (K)-specific demethylase 6B
• NCBI Official Symbol: Kdm6b
• NCBI Official Synonym Symbols: Jmjd3; BC038313; mKIAA0346; 1700064E03Rik
• NCBI Protein Information: lysine-specific demethylase 6B
• UniProt Protein Name: Lysine-specific demethylase 6B
• Protein Family: Lysine-specific demethylase
• UniProt Gene Name: Kdm6b
• UniProt Synonym Gene Names: Jmjd3; Kiaa0346
• UniProt Entry Name: KDM6B_MOUSE

Uniprot Description

JMJD3: Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Interacts with TLE1. Component of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and KDM6B. By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Belongs to the UTX family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-; Oxidoreductase

Cellular Component: nucleus

Molecular Function: beta-catenin binding; chromatin binding; sequence-specific DNA binding

Biological Process: cardiac muscle cell differentiation; cell fate commitment; endothelial cell differentiation; hippocampus development; histone demethylation; mesodermal cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression