Western Blot (WB)
(Anti-KDM6B Antibody (Center) at 1:2000 dilution + mouse lung lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 177 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Rabbit anti-Mouse KDM6B Polyclonal Antibody | anti-KDM6B antibody
KDM6B Antibody (Center)
Western Blot (WB)
(Anti-KDM6B Antibody (Center) at 1:2000 dilution + mouse lung lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 177 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Western Blot (WB)
(Anti-KDM6B Antibody (Center) at 1:2000 dilution + mouse lung lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 177 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Hu L.Y.,et al.Gene Expr. 13:179-189(2006).
De Santa F.,et al.Cell 130:1083-1094(2007).
NCBI and Uniprot Product Information
Uniprot Description
JMJD3: Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Interacts with TLE1. Component of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and KDM6B. By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Belongs to the UTX family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.11.-; Oxidoreductase
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; dioxygenase activity; sequence-specific DNA binding; metal ion binding; beta-catenin binding
Biological Process: endothelial cell differentiation; establishment and/or maintenance of chromatin architecture; mesodermal cell differentiation; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; cardiac muscle cell differentiation
Research Articles on KDM6B
Similar Products
Product Notes
The KDM6B kdm6b (Catalog #AAA9213941) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KDM6B Antibody (Center) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's KDM6B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:2000. Researchers should empirically determine the suitability of the KDM6B kdm6b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KDM6B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
