Mouse lysine (K) -specific demethylase 2B ELISA Kit | KDM2B elisa kit
Mouse Lysine-specific demethylase 2B, KDM2B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a H3K36-specific histone demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Description
FBXL10: Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Belongs to the JHDM1 histone demethylase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; DNA-binding; Demethylase; EC 1.14.11.27; Oxidoreductase
Cellular Component: PcG protein complex; nucleus
Molecular Function: rRNA binding; protein binding; DNA binding; histone demethylase activity; dioxygenase activity; zinc ion binding; RNA binding; histone demethylase activity (H3-K36 specific); metal ion binding; oxidoreductase activity
Biological Process: midbrain-hindbrain boundary morphogenesis; transcription, DNA-dependent; fourth ventricle development; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; third ventricle development; initiation of neural tube closure; histone demethylation; regulation of transcription, DNA-dependent; forebrain development; midbrain development; spermatogenesis; negative regulation of neuron apoptosis; embryonic camera-type eye morphogenesis; lateral ventricle development; hindbrain development
Research Articles on KDM2B
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Product Notes
The Mouse KDM2B kdm2b (Catalog #AAA9330185) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330185 ELISA Kit recognizes Mouse KDM2B. It is sometimes possible for the material contained within the vial of "lysine (K) -specific demethylase 2B, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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