JHDM1a/FBXL11 Blocking Peptide | KDM2A blocking peptide

JHDM1a/FBXL11 Blocking Peptide (C-term)

• Gene Names: KDM2A; FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA
• Synonyms: JHDM1a/FBXL11; JHDM1a/FBXL11 Blocking Peptide (C-term); Lysine-specific demethylase 2A; CXXC-type zinc finger protein 8; F-box and leucine-rich repeat protein 11; F-box protein FBL7; F-box protein Lilina; F-box/LRR-repeat protein 11; JmjC domain-containing histone demethylation protein 1A; [Histone-H3]-lysine-36 demethylase 1A; KDM2A; CXXC8; FBL7; FBXL11; JHDM1A; KIAA1004; KDM2A blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 882-896 of HUMAN KDM2A
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1162

• Cellular Location: Nucleus, nucleoplasm Note: Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2
• Tissue Location: Widely expressed, with highest levels in brain, testis and ovary, followed by lung
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for KDM2A blocking peptide

Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.

NCBI and Uniprot Product Information

• NCBI GI #: 38257795
• NCBI GeneID: 22992
• UniProt Accession #: Q9Y2K7; Q49A21; Q4G0M3; Q69YY8; Q9BVH5; Q9H7H5; Q9UK66; D4QA03; E9PIL6; I3VM55
• Molecular Weight: 89,948 Da
• NCBI Official Full Name: Lysine-specific demethylase 2A
• NCBI Official Synonym Full Names: lysine demethylase 2A
• NCBI Official Symbol: KDM2A
• NCBI Official Synonym Symbols: FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA
• NCBI Protein Information: lysine-specific demethylase 2A
• UniProt Protein Name: Lysine-specific demethylase 2A
• Protein Family: Lysine-specific demethylase
• UniProt Gene Name: KDM2A
• UniProt Synonym Gene Names: CXXC8; FBL7; FBXL11; JHDM1A; KIAA1004
• UniProt Entry Name: KDM2A_HUMAN

NCBI Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Description

FBXL11: Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Belongs to the JHDM1 histone demethylase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Demethylase; EC 1.14.11.27

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: nucleolus; nucleoplasm; nucleus

Molecular Function: histone demethylase activity

Biological Process: double-strand break repair via nonhomologous end joining