Western Blot (WB)
(Western blot analysis of anti-JHDM1a/FBXL11 Antibody (C-term) pre-incubated with(right lane) and without(left lane) blocking peptide in Jurkat cell line lysate. JHDM1a(arrow) was detected using the purified Pab.)
Rabbit anti-Human JHDM1a Polyclonal Antibody | anti-JHDM1a antibody
JHDM1a, CT (FBXL11) (KDM2A, CXXC8, FBL7, FBXL11, JHDM1A, KIAA1004, Lysine-specific demethylase 2A, CXXC-type zinc finger protein 8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, F-box/LRR-repeat protein 11, JmjC domai
FLISA: 1:1,000
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of anti-JHDM1a/FBXL11 Antibody (C-term) pre-incubated with(right lane) and without(left lane) blocking peptide in Jurkat cell line lysate. JHDM1a(arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of anti-JHDM1a/FBXL11 Antibody (C-term) pre-incubated with(right lane) and without(left lane) blocking peptide in Jurkat cell line lysate. JHDM1a(arrow) was detected using the purified Pab.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Uniprot Description
FBXL11: Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Belongs to the JHDM1 histone demethylase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; Demethylase; EC 1.14.11.27
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: nucleoplasm; nuclear chromatin; nucleolus; nucleus
Molecular Function: unmethylated CpG binding; zinc ion binding; histone demethylase activity (H3-K36 specific)
Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; double-strand break repair via nonhomologous end joining
Research Articles on JHDM1a
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Product Notes
The JHDM1a kdm2a (Catalog #AAA6311585) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The JHDM1a, CT (FBXL11) (KDM2A, CXXC8, FBL7, FBXL11, JHDM1A, KIAA1004, Lysine-specific demethylase 2A, CXXC-type zinc finger protein 8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, F-box/LRR-repeat protein 11, JmjC domai reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's JHDM1a can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:50-100 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the JHDM1a kdm2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "JHDM1a, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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