Potassium voltage-gated channel subfamily KQT member 4 (Kcnq4) Recombinant Protein | Kcnq4 recombinant protein
Recombinant Mouse Potassium voltage-gated channel subfamily KQT member 4 (Kcnq4)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
KCNQ4: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic receptors. Defects in KCNQ4 are the cause of deafness autosomal dominant type 2A (DFNA2A). DFNA2A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: cytoplasm; integral to membrane; membrane; neuron projection; plasma membrane; voltage-gated potassium channel complex
Molecular Function: delayed rectifier potassium channel activity; ion channel activity; potassium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity
Biological Process: inner ear morphogenesis; ion transport; negative regulation of synaptic transmission, dopaminergic; potassium ion transport; sensory perception of sound; transmembrane transport; transport
Research Articles on Kcnq4
Similar Products
Product Notes
The Kcnq4 kcnq4 (Catalog #AAA7017779) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-696aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Kcnq4 kcnq4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MAEAPPRRLG LGPPPGDAPR AELVALTAVQ SEQGEAGGGG SPRRLGLLGS PLPPGAPLPG PGSGSGSACG GQRSSAAQKR YRRLQNWVYN VLERPRGWAF VYHVFIFLLV FSCLVLSVLS TIQEHQELAN ECLLILEFVM IVVFGLEYII RVWSAGCCCR YRGWQGRFRF ARKPFCVIDF IVFVASVAVI AAGTQGNIFA TSALRSMRFL QILRMVRMDR RGGTWKLLGS VVYAHSKELI TAWYIGFLVL IFASFLVYLA EKDANSDFSS YADSLWWGTI TLTTIGYGDK TPHTWLGRVL AAGFALLGIS FFALPAGILG SGFALKVQEQ HRQKHFEKRR MPAANLIQAA WRLYSTDTSR AYLTATWYYY DSILPSFREL ALLFEHIQRA RNGGLRPLEV RRAPVPDGAP SRYPPVATCH RPGSASFCPG ESSRMGIKDR IRISSSQKRT GPSKQHLAPP PIPTSPSSEQ VGEASSPSKV QKSWSFNDRT RFRASLRLKP RCSAEEGPSE EVAEEKSYQC ELTVDDVMPA VKTVIRSVRI LKFLVAKRKF KETLRPYDVK DVIEQYSAGH LDMLGRIKSL QARVDQIVGR GPGDRKTREK GDKGPSDTEA VDEISMMGRV VKVEKQVQSI EHKLDLLLGF YSRCLRSGTS ASLGTVQVPL FDPDITSDYH SPVDHEDISV SAQTLSISRS VSTNMD. It is sometimes possible for the material contained within the vial of "Potassium voltage-gated channel subfamily KQT member 4 (Kcnq4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
