Potassium channel subfamily K member 4 (KCNK4) Recombinant Protein | KCNK4 recombinant protein

Recombinant Human Potassium channel subfamily K member 4 (KCNK4), partial

• Gene Names: KCNK4; TRAAK; K2p4.1; TRAAK1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Potassium channel subfamily K member 4 (KCNK4); Recombinant Human Potassium channel subfamily K member 4 (KCNK4); partial; KCNK4 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 419

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 952977797
• NCBI GeneID: 50801
• NCBI Accession #: NP_001304019.1
• NCBI GenBank Nucleotide #: NM_001317090.1
• UniProt Accession #: Q9NYG8; Q96T94; B5TJL1
• Molecular Weight: 45,173 Da
• NCBI Official Full Name: potassium channel subfamily K member 4
• NCBI Official Synonym Full Names: potassium two pore domain channel subfamily K member 4
• NCBI Official Symbol: KCNK4
• NCBI Official Synonym Symbols: TRAAK; K2p4.1; TRAAK1
• NCBI Protein Information: potassium channel subfamily K member 4
• UniProt Protein Name: Potassium channel subfamily K member 4
• Protein Family: Potassium channel subfamily
• UniProt Gene Name: KCNK4
• UniProt Synonym Gene Names: TRAAK; Two pore K(+) channel KT4.1

NCBI Description

This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]

Uniprot Description

Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157). Channel opening is triggered by raising the intracellular pH to basic levels (). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (). Plays a role in the perception of pain caused by heat (). Plays a role in the sensory perception of pain caused by pressure ().