anti-Human, Mouse KCNK4 Antibody | anti-KCNK4 antibody

KCNK4 Antibody

Cat. Num. AAA8515013

• Gene Names: KCNK4; TRAAK; K2p4.1; TRAAK1
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Immunogen affinity purified
• Synonyms: KCNK4; KCNK4 Antibody; K2p4.1; potassium channel; subfamily K; member 4; TRAAK; TRAAK1; TWIK-related arachidonic acid-stimulated potassium channel; two pore K(+) channel KT4.1; anti-KCNK4 antibody

• Reactivity: Human, Mouse
• Specificity: KCNK4 Antibody detects endogenous levels of total KCNK4
• Purity/Purification: Immunogen affinity purified
• Form/Format: In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 393

• Applicable Applications for anti-KCNK4 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthesized peptide
• Preparation and Storage: Store at-20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from HT-29 cells, using KCNK4 antibody.)

NCBI and Uniprot Product Information

• NCBI GI #: 952977797
• NCBI GeneID: 50801
• NCBI Accession #: NP_001304019.1
• NCBI GenBank Nucleotide #: NM_001317090.1
• UniProt Accession #: Q9NYG8; Q96T94; B5TJL1
• Molecular Weight: 45 KD
• NCBI Official Full Name: potassium channel subfamily K member 4
• NCBI Official Synonym Full Names: potassium two pore domain channel subfamily K member 4
• NCBI Official Symbol: KCNK4
• NCBI Official Synonym Symbols: TRAAK; K2p4.1; TRAAK1
• NCBI Protein Information: potassium channel subfamily K member 4
• UniProt Protein Name: Potassium channel subfamily K member 4
• Protein Family: Potassium channel subfamily
• UniProt Gene Name: KCNK4
• UniProt Synonym Gene Names: TRAAK; Two pore K(+) channel KT4.1

NCBI Description

This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]

Uniprot Description

Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157). Channel opening is triggered by raising the intracellular pH to basic levels (). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (). Plays a role in the perception of pain caused by heat (). Plays a role in the sensory perception of pain caused by pressure ().