SDS-PAGE
Jumping Translocation Breakpoint / JTB Recombinant Protein | JTB recombinant protein
Recombinant Human Jumping Translocation Breakpoint / JTB Protein (Fc tag)
Gene Names
JTB; PAR; hJT; HJTB; HSPC222
Purity
> 85 % as determined by SDS-PAGE
Synonyms
Jumping Translocation Breakpoint / JTB; Recombinant Human Jumping Translocation Breakpoint / JTB Protein (Fc tag); JTB; JTB recombinant protein
Host
Human Cells
Purity/Purification
> 85 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
146
Application Notes
The recombinant human JTB/mFc is a disulfide-linked homodimer. The reduced monomer comprises 309 amino acids and has a predicted molecular mass of 34.7 kDa. The apparent molecular mass of the protein is approximately 38 in SDS-PAGE under reducing conditions due to glycosylation.
Predicted N Terminal
Glu 31
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for JTB recombinant protein
Background: Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomalsegments jumping to various telomeres. JTB is expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. It is required for normal cytokinesis during mitosis. JTB plays a role in the regulation of cell proliferation. It may be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.
Description: A DNA sequence encoding the human JTB (O76095-1) (Met1-Leu105) was fused with Fc region of mouse IgG at the C-terminus.
Description: A DNA sequence encoding the human JTB (O76095-1) (Met1-Leu105) was fused with Fc region of mouse IgG at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
13,356 Da
NCBI Official Full Name
protein JTB
NCBI Official Synonym Full Names
jumping translocation breakpoint
NCBI Official Symbol
JTB
NCBI Official Synonym Symbols
PAR; hJT; HJTB; HSPC222
NCBI Protein Information
protein JTB
UniProt Protein Name
Protein JTB
Protein Family
UniProt Gene Name
JTB
UniProt Synonym Gene Names
PAR protein
Uniprot Description
JTB: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. Belongs to the JTB family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: centrosome; cytoplasm; integral to plasma membrane; membrane; midbody; spindle
Molecular Function: protein kinase binding
Biological Process: cytokinesis; mitosis; positive regulation of protein kinase activity
Research Articles on JTB
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Product Notes
The JTB jtb (Catalog #AAA2545309) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant human JTB/mFc is a disulfide-linked homodimer. The reduced monomer comprises 309 amino acids and has a predicted molecular mass of 34.7 kDa. The apparent molecular mass of the protein is approximately 38 in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the JTB jtb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Jumping Translocation Breakpoint / JTB, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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