Human jumonji domain containing 1A ELISA Kit | JMJD1A elisa kit
Human Lysine-specific demethylase 3A, JMJD1A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Description
JMJD1A: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. Belongs to the JHDM2 histone demethylase family.
Protein type: Demethylase; Nuclear receptor co-regulator; Oxidoreductase; EC 1.14.11.-
Chromosomal Location of Human Ortholog: 2p11.2
Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus
Molecular Function: androgen receptor binding; dioxygenase activity; iron ion binding; transcription factor activity
Biological Process: negative regulation of histone H3-K9 methylation; formaldehyde biosynthetic process; establishment and/or maintenance of chromatin architecture; spermatid nuclear elongation; histone H3-K9 demethylation; hormone-mediated signaling; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter
Research Articles on JMJD1A
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Product Notes
The Human JMJD1A kdm3a (Catalog #AAA9330436) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330436 ELISA Kit recognizes Human JMJD1A. It is sometimes possible for the material contained within the vial of "jumonji domain containing 1A, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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