Rabbit anti-Human CRELD2 Polyclonal Antibody | anti-CRELD2 antibody

CRELD2 Rabbit pAb

Cat. Num. AAA4760042

• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: CRELD2; Polyclonal Antibody; CRELD2 Rabbit pAb; cysteine-rich with EGF-like domains 2; anti-CRELD2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 0.3mg/ml (varies by lot)

• Applicable Applications for anti-CRELD2 antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:500-1:2000; IHC-P: 1:50-1:200
• Immunogen: Fusion protein of human CRELD2
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western Blot analysis of CRELD2 in Human normal colon tissue using CRELD2 Rabbit pAb at dilution 1/550)

Immunohistochemistry (IHC)

(Immunohistochemistry of CRELD2 in paraffin-embedded Human thyroid cancer tissue using CRELD2 Rabbit pAb at dilution 1/50. Predicted cell location: Cytoplasm)

Related Product Information for anti-CRELD2 antibody

The epidermal growth factor (EGF) repeat-containing proteins constitute an expanding family of proteins that are involved in several cellular activities, such as blood coagulation, fibrinolysis, cell adhesion and neural and vertebrate development. CRELD2 (cysteine-rich with EGF-like domains 2) is a 353 amino acid protein that is ubiquitously expressed and contains two FU domains and two EGF-like domains. Localized to the endoplasmic reticulum and secreted into the cell, CRELD2 interacts with AChRå4, possibly regulating its transport. Human CRELD2 shares 69% amino acid identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of CRELD2 exist due to alternative splicing events. The gene encoding CRELD2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.

NCBI and Uniprot Product Information

• NCBI GI #: 205360956
• NCBI GeneID: 79174
• NCBI Accession #: NP_001128573.1
• NCBI GenBank Nucleotide #: NM_001135101.2
• UniProt Accession #: Q6UXH1; Q4W0V0; Q86UC0; Q9BU47; A5GZA2; A5GZA3; A5GZA4; A5GZA5; A5GZA6
• Molecular Weight: 38,192 Da
• NCBI Official Full Name: cysteine-rich with EGF-like domain protein 2 isoform a
• NCBI Official Synonym Full Names: cysteine-rich with EGF-like domains 2
• NCBI Official Symbol: CRELD2
• NCBI Protein Information: cysteine-rich with EGF-like domain protein 2
• UniProt Protein Name: Cysteine-rich with EGF-like domain protein 2
• Protein Family: Cysteine-rich with EGF-like domain protein
• UniProt Gene Name: CRELD2
• UniProt Synonym Gene Names: UNQ185/PRO211
• UniProt Entry Name: CREL2_HUMAN

Uniprot Description

CRELD2: May regulate transport of alpha4-beta2 neuronal acetylcholine receptor. Belongs to the CRELD family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum

Molecular Function: protein binding; calcium ion binding