SDS-PAGE
IZUMO4 / C19orf36 recombinant protein
Recombinant Human IZUMO4 / C19orf36 Protein (Fc tag)
Gene Names
IZUMO4; C19orf36; IMAGE:4215339
Purity
> 96 % as determined by SDS-PAGE
Synonyms
IZUMO4 / C19orf36; Recombinant Human IZUMO4 / C19orf36 Protein (Fc tag); C19orf36; IZUMO4; IZUMO4 / C19orf36 recombinant protein
Host
Human Cells
Purity/Purification
> 96 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
214
Application Notes
The recombinant human C19orf36/Fc comprises 438 amino acids and has a predicted molecular mass of 49.8 kDa. The apparent molecular mass of the protein is approximately 55-59 kDa in SDS-PAGE under reducing conditions.
Predicted N Terminal
Cys 18
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for IZUMO4 / C19orf36 recombinant protein
Background: Izumo is a sperm membrane protein which plays a key role in the fusion in the mouse. It has an Immunoglobulin (Ig) domain and an N-terminal domain for which neither the functions nor homologous sequences are known. Up to now, there four members has an N-terminal domain with significant homology to the N-terminal domain of Izumo. We call this domain Izumo domain. The four proteins are Izumo 1, 2, 3, and 4. Izumo domain possesses the ability to form dimers, whereas the transmembrane domain or the cytoplasmic domain or both of Izumo 1 are required for the formation of multimers of higher order. Izumo 1-3 are transmembrane proteins expressed specifically in the testis, and Izumo 4 is a soluble protein expressed in the testis and in other tissues. Izumo 1, 3, and 4 formed protein complexes on sperm, Izumo 1 forming several larger complexes and Izumo 3 and 4 forming a single larger complex. Co-immunoprecipitation studies showed the presence of other sperm proteins associated with Izumo 1, suggesting Izumo 1 forms a multiprotein membrane complex.
Description: A DNA sequence encoding the human C19orf36 (Q1ZYL8) (Met1-His214) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Description: A DNA sequence encoding the human C19orf36 (Q1ZYL8) (Met1-His214) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18,245 Da
NCBI Official Full Name
izumo sperm-egg fusion protein 4 isoform 1
NCBI Official Synonym Full Names
IZUMO family member 4
NCBI Official Symbol
IZUMO4
NCBI Official Synonym Symbols
C19orf36; IMAGE:4215339
NCBI Protein Information
izumo sperm-egg fusion protein 4
UniProt Protein Name
Izumo sperm-egg fusion protein 4
UniProt Gene Name
IZUMO4
UniProt Synonym Gene Names
C19orf36
Uniprot Description
IZUMO4: Belongs to the Izumo family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: nucleus
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Product Notes
The IZUMO4 / C19orf36 izumo4 (Catalog #AAA2545350) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant human C19orf36/Fc comprises 438 amino acids and has a predicted molecular mass of 49.8 kDa. The apparent molecular mass of the protein is approximately 55-59 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the IZUMO4 / C19orf36 izumo4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IZUMO4 / C19orf36, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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