Mouse inositol 1, 4, 5-triphosphate receptor, type 1 ELISA Kit | ITPR1 elisa kit
Mouse Inositol 1, 4, 5-trisphosphate receptor type 1, ITPR1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
IP3R1: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaMKII, eventually leading to the activation of downstream apoptosis pathways. Part of a cGMP kinase signaling complex that includes alpha-actin, calponin H1, phospholamban, PKG1 and IP3R1. Widely expressed. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA prevents the ligand-induced opening of the calcium channels. Belongs to the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family. Eight alternatively spliced isoforms have been described.
Protein type: Channel, calcium; Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated
Cellular Component: endoplasmic reticulum membrane; protein complex; intracellular membrane-bound organelle; sarcoplasmic reticulum; cell; endoplasmic reticulum; secretory granule membrane; dendrite; postsynaptic density; integral to membrane; nuclear inner membrane; nuclear envelope; cytosol; calcineurin complex; lipid raft; cell soma; membrane; perinuclear region of cytoplasm; cytoplasm; nucleolus; plasma membrane; platelet dense granule membrane; intracellular
Molecular Function: protein C-terminus binding; protein binding; calcium channel activity; ion channel activity; protein complex binding; calcium channel inhibitor activity; intracellular ligand-gated calcium channel activity; protein phosphatase binding; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity
Biological Process: negative regulation of calcium-mediated signaling; voluntary musculoskeletal movement; inositol phosphate-mediated signaling; apoptosis; post-embryonic development; endoplasmic reticulum calcium ion homeostasis; elevation of cytosolic calcium ion concentration; transport; release of sequestered calcium ion into cytosol; calcium ion transport; response to hypoxia; ion transport; positive regulation of calcium ion transport; transmembrane transport
Research Articles on ITPR1
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Product Notes
The Mouse ITPR1 itpr1 (Catalog #AAA9322627) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322627 ELISA Kit recognizes Mouse ITPR1. It is sometimes possible for the material contained within the vial of "inositol 1, 4, 5-triphosphate receptor, type 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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