Integral membrane protein 2B (ITM2B) Recombinant Protein | ITM2B recombinant protein

Recombinant Human Integral membrane protein 2B (ITM2B), partial

Cat. Num. AAA1338554

• Gene Names: ITM2B; BRI; FBD; ABRI; BRI2; E25B; E3-16; RDGCA; imBRI2; BRICD2B
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Integral membrane protein 2B (ITM2B); Recombinant Human Integral membrane protein 2B (ITM2B); partial; ITM2B recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-54
• Sequence: MVKVTFNSAL AQKEAKKDEP KSGEEALIIP PDAVAVDCKD PDDVVPVGQR RAWC
• Sequence Length: 54

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for ITM2B recombinant protein

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

NCBI and Uniprot Product Information

• NCBI GI #: 11527402
• NCBI GeneID: 9445
• NCBI Accession #: NP_068839.1
• NCBI GenBank Nucleotide #: NM_021999.4
• UniProt Accession #: Q9Y287; Q5W0A3; Q96B24; Q9NYH1
• Molecular Weight: 18,283 Da
• NCBI Official Full Name: integral membrane protein 2B
• NCBI Official Synonym Full Names: integral membrane protein 2B
• NCBI Official Symbol: ITM2B
• NCBI Official Synonym Symbols: BRI; FBD; ABRI; BRI2; E25B; E3-16; RDGCA; imBRI2; BRICD2B
• NCBI Protein Information: integral membrane protein 2B
• UniProt Protein Name: Integral membrane protein 2B
• Protein Family: Integral membrane protein
• UniProt Gene Name: ITM2B
• UniProt Synonym Gene Names: BRI; BRI2; imBRI2; Bri; mBRI2; BRI2 ICD; Bri2-23

NCBI Description

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]

Uniprot Description

Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.