Integrin beta-3 Recombinant Protein | Itgb3 recombinant protein
Integrin beta-3
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Cellular Component: apical plasma membrane; cell surface; external side of plasma membrane; filopodium membrane; focal adhesion; integrin complex; melanosome; membrane; microvillus membrane; nucleus; plasma membrane; receptor complex
Molecular Function: C-X3-C chemokine binding; cell adhesion molecule binding; enzyme binding; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; identical protein binding; insulin-like growth factor I binding; integrin binding; peptide binding; protease binding; protein binding; protein disulfide isomerase activity; vascular endothelial growth factor receptor 2 binding
Biological Process: activation of protein kinase activity; cell adhesion; cell growth; cell migration; cell projection morphogenesis; cell-matrix adhesion; cell-substrate adhesion; cell-substrate junction assembly; cellular calcium ion homeostasis; entry of virus into host cell; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; platelet activation; platelet-derived growth factor receptor signaling pathway; positive regulation of angiogenesis; positive regulation of bone resorption; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of cell-matrix adhesion; positive regulation of endothelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of leukocyte migration; positive regulation of MAPKKK cascade; positive regulation of osteoblast proliferation; positive regulation of osteoclast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; regulation of actin cytoskeleton organization and biogenesis; regulation of cell migration; regulation of G-protein coupled receptor protein signaling pathway; regulation of release of sequestered calcium ion into cytosol; smooth muscle cell migration
Research Articles on Itgb3
Similar Products
Product Notes
The Itgb3 itgb3 (Catalog #AAA7042956) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 26-787aa; full length protein. The amino acid sequence is listed below: ESNICTTRGV NSCQQCLAVS PVCAWCSDET LSQGSPRCNL KENLLKDNCA PESIEFPVSE AQILEARPLS SKGSGSSAQI TQVSPQRIAL RLRPDDSKIF SLQVRQVEDY PVDIYYLMDL SFSMKDDLSS IQTLGTKLAS QMRKLTSNLR IGFGAFVDKP VSPYMYISPP QAIKNPCYNM KNACLPMFGY KHVLTLTDQV SRFNEEVKKQ SVSRNRDAPE GGFDAIMQAT VCDEKIGWRN DASHLLVFTT DAKTHIALDG RLAGIVLPND GHCHIGTDNH YSASTTMDYP SLGLMTEKLS QKNINLIFAV TENVVSLYQN YSELIPGTTV GVLSDDSSNV LQLIVDAYGK IRSKVELEVR DLPEELSLSF NATCLNNEVI PGLKSCVGLK IGDTVSFSIE AKVRGCPQEK EQSFTIKPVG FKDSLTVQVT FDCDCACQAF AQPSSPRCNN GNGTFECGVC RCDQGWLGSM CECSEEDYRP SQQEECSPKE GQPICSQRGE CLCGQCVCHS SDFGKITGKY CECDDFSCVR YKGEMCSGHG QCNCGDCVCD SDWTGYYCNC TTRTDTCMST NGLLCSGRGN CECGSCVCVQ PGSYGDTCEK CPTCPDACSF KKECVECKKF NRGTLHEENT CSRYCRDDIE QVKELTDTGK NAVNCTYKNE DDCVVRFQYY EDTSGRAVLY VVEEPECPKG PDILVVLLSV MGAILLIGLA TLLIWKLLIT IHDRKEFAKF EEERARAKWD TANNPLYKEA TSTFTNITYR GT. It is sometimes possible for the material contained within the vial of "Integrin beta-3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
