Mouse iron-sulfur cluster scaffold homolog (E. coli) ELISA Kit | ISCU elisa kit
Mouse Iron-sulfur cluster assembly enzyme ISCU, mitochondrial, ISCU ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ISCU: Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron. Defects in ISCU are the cause of myopathy with exercise intolerance Swedish type (MEIS); also known as myopathy with deficiency of succinate dehydrogenase and aconitase or myoglobinuria due to abnormal glycolysis or hereditary myopathy with lactic acidosis (HML). This autosomal recessive metabolic disease is characterized by lifelong severe exercise intolerance, in which minor exertion causes fatigue of active muscles, shortness of breath, and cardiac palpitations in association with lactic acidosis. The biochemical phenotype is characterized by a deficiency in mitochondrial iron-sulfur proteins and impaired muscle oxidative metabolism. Belongs to the NifU family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial
Cellular Component: mitochondrion; cytoplasm; cytosol
Molecular Function: metal ion binding; iron ion binding; iron-sulfur cluster binding; protein complex scaffold
Biological Process: iron-sulfur cluster assembly
Research Articles on ISCU
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Product Notes
The Mouse ISCU iscu (Catalog #AAA9327411) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327411 ELISA Kit recognizes Mouse ISCU. It is sometimes possible for the material contained within the vial of "iron-sulfur cluster scaffold homolog (E. coli), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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