OX40 ligand, soluble Active Protein | OX40 ligand active protein
Human OX40 ligand, soluble
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Subunit structure: Homotrimer. Ref.8
Subcellular location: Membrane; Single-pass type II membrane protein.
Induction: By HTLV-1 transactivator p40-Tax.
Involvement in disease: Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Ref.7
Sequence similarities: Belongs to the tumor necrosis factor family.
Sequence caution: The sequence CAA18438.2 differs from that shown. Reason: Erroneous gene model prediction.
Research Articles on OX40 ligand
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Product Notes
The OX40 ligand tnfsf4 (Catalog #AAA691527) is an Active Protein produced from Insect Cells and is intended for research purposes only. The product is available for immediate purchase. The Human OX40 ligand, soluble reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: QVSHRYPRIQ SIKVQFTEYK KEKGFILTSQ KEDEIMKVQN NSVIIN CDGF YLISLKGYFS QEVNISLHYQ KDEEPLFQLK KVRSVNSLMV A SLTYKDKVY LNVTTDNTSL DDFHVNGGEL ILIHQNPGEF CVL. It is sometimes possible for the material contained within the vial of "OX40 ligand, soluble, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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