Structure
ZLN024 hydrochloride, Inhibitor | ZLN024, inhibitor
ZLN024 hydrochloride
Purity
98.00%
Synonyms
ZLN024 hydrochloride; ZLN024; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 46mg/mL (127.18mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C13H14BrClN2OS
SMILES
CC1=CC=C(OCCSC2=NC=CC=N2)C(Br)=C1.[H]Cl
Target & IC50
AMPK alpha2beta2gamma1: ic50 0.13uM (EC50)
AMPK alpha1beta1gamma1: ic50 0.42uM (EC50)
AMPK alpha2beta1gamma1: ic50 0.95uM (EC50)
AMPK alpha1beta1gamma1: ic50 0.42uM (EC50)
AMPK alpha2beta1gamma1: ic50 0.95uM (EC50)
In Vitro
C57BKS db/db mice are administered a 15mg/kg/day dose of ZLN024 by daily gavage for 5 weeks; 250mg/kg/day Metformin (Met) is used as a positive control. After 4 weeks of treatment, ZLN024 improves glucose tolerance. ZLN024 reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content are decreased.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for ZLN024, inhibitor
ZLN024 hydrochloride is an activator of AMPK allosteric.
Product Categories/Family for ZLN024, inhibitor
References
Zhang LN, et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One. 2013 Aug 20;8(8):e72092.
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Product Notes
The ZLN024 (Catalog #AAA5754167) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ZLN024 hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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