Structure
ZL0420, Inhibitor
ZL0420
Purity
>98% (HPLC)
Synonyms
ZL0420; ZL-0420; ZL 0420; inhibitor
Purity/Purification
>98% (HPLC)
Target
Bromodomain
Receptor
Bromodomain
Chemical Name
(E)-6-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-3, 4-dihydroquinolin-2(1H)-one
SMILES
CC1=C(O)C=C(N)C(/N=N/C2=CC(CCC(N3)=O)=C3C=C2)=C1
Molecular Formula
C16H16N4O2
CAS Number
2229039-45-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ZL0420, inhibitor
ZL0420 is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32nM for BRD4-BD1 and BRD4-BD2, respectively; displays selectivity over BRD2, BRD3, and BRDT (BRD2-BD1 and BRD2-BD2, IC50=803 and 1736nM); disrupts the BRD4 complex with Pol II and histones, inhibits poly (I:C)-induced expression of innate immune genes IL6 and CIG5 in human small airway epithelial cells (hSAECs) (IC50=0.54 and 0.51uM); blocks Poly (I:C)-induced inflammation and neutrophilia in vivo.
Product Categories/Family for ZL0420, inhibitor
References
1. Tian B, et al. Cell Rep. 2018 Apr 24; 23 (4):1138-1151.
2. Liu Z, et al. Eur J Med Chem 2018 May 10; 151:450-461.
2. Liu Z, et al. Eur J Med Chem 2018 May 10; 151:450-461.
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Product Notes
The ZL0420 (Catalog #AAA3603566) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ZL0420, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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