Structure
PLX51107, Inhibitor
PLX51107
Purity
>98% (HPLC)
Synonyms
PLX51107; PLX 51107; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 75mg/mL (171.05mM)
Target
Bromodomain
Receptor
Bromodomain
Chemical Name
(S)-4-(6-(3, 5-dimethylisoxazol-4-yl)-1-(1-(pyridin-2-yl)ethyl)-1H-pyrrolo[3, 2-b]pyridin-3-yl)benzoic acid
SMILES
O=C(O)C1=CC=C(C2=CN([C@H](C3=NC=CC=C3)C)C4=CC(C5=C(C)ON=C5C)=CN=C42)C=C1
Molecular Formula
C26H22N4O3
CAS Number
1627929-55-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PLX51107, inhibitor
PLX51107 is a novel structurally distinct BET bromodomain inhibitor that inhibits all four BET family proteins BRD2, BRD3, BRD4, and BRDT with low nanomolar potency; exhibits modest preference for BD1 versus BD2 within each BET protein (Kd=1.6, 2.1, 1.7, and 5nM for BD1 and 5.9, 6.2, 6.1 and 120nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively). Potently reduces viability and proliferation of the human AML cell lines MV4-11, MOLM-13, OCI-AML3, and Kasumi-1 with IC50 of 0.17, 1.8, 0.2 and 0.2uM, respectively; has sufficient potency and oral bioavailability to demonstrate in vivo efficacy in animal models of a variety of tumor types. Blood Cancer Phase 1 Clinical
Product Categories/Family for PLX51107, inhibitor
References
1.Ozer HG, et al. Cancer Discov. 2018 Jan 31. pii: CD-17-0902.
2.Nicole R. Grieselhuber, et al. Blood 2016 128:3941.
2.Nicole R. Grieselhuber, et al. Blood 2016 128:3941.
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Product Notes
The PLX51107 (Catalog #AAA3602420) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PLX51107, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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