Wilfortrine, Inhibitor
Wilfortrine
Purity
98.00%
Synonyms
Wilfortrine; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C41H47NO20
SMILES
C[C@](COC(c1c(CC[C@](C)(C(O[C@@H]([C@@H]2OC(c3cocc3)=O)[C@]3(C)O)=O)O)nccc1)=O)([C@@H]([C@H]1OC(C)=O)[C@H]([C@H]4OC(C)=O)OC(C)=O)O[C@]13[C@@]4(COC(C)=O)[C@H]2OC(C)=O
CAS Number
37239-48-8
Target & IC50
Bcl-2
Immunology & Inflammation related
Immunology & Inflammation related
In Vitro
We investigated the role of Wilfortrine on liver cancer cell HepG2 apoptosis and analyzed its possible mechanisms to provide a theoretical basis for clinical analysis of liver cancer pathogenesis. The liver cancer cell line HepG2 was treated with 40mM Wilfortrine for 48 hours. Flow cytometry was applied to detect HepG2 cell apoptosis and cell cycle changes. Western blot was used to analyze Bcl-2 and Bax expression. The HepG2 cell apoptosis rate increased significantly after treatment with Wilfortrine, especially the early apoptosis rate (P <0.05). However, Wilfortrine did not change the cell cycle of HepG2 cells. After Wilfortrine treatment, Bcl- 2 expression decreased significantly (P <0.05); on the contrary, Bax expression increased noticeably compared with the control group (P <0.05).
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Wilfortrine, inhibitor
Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic protein Bcl-2 expression.
Product Categories/Family for Wilfortrine, inhibitor
References
Effect of wilfortrine on human hepatic cancer HepG2 cell proliferation potential in vitro.Genet Mol Res. 2015 Nov 30;14(4):15349-55.
Similar Products
Product Notes
The Wilfortrine (Catalog #AAA5761012) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Wilfortrine, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
