Structure
VX-765 Biochemical
VX-765
Purity
>98% (HPLC)
Synonyms
VX-765; Belnacasan; VX765; VX 765; VX-765 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=27mg/mL
Target
Caspase
Receptor
Caspase-1; Caspase-4
Chemical Name
L-Prolinamide, N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R, 3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]
SMILES
O=C([C@H]1N(C([C@@H](NC(C2=CC=C(N)C(Cl)=C2)=O)C(C)(C)C)=O)CCC1)N[C@@H](C3)[C@H](OCC)OC3=O
Molecular Formula
C24H33ClN4O6
CAS Number
273404-37-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for VX-765 biochemical
VX-765 (Belnacasan) is an orally absorbed prodrug of VRT-043198, which is a potent and selective inhibitor of interleukin-converting enzyme/caspase-1 with Ki of 0.8nM; VRT-043198 exhibits 100- to 10,000-fold selectivity against other caspase-3 and -6 to -9, VX-765 is converted rapidly to VRT-043198 under the action of plasma and liver esterases; inhibits LPS-induced IL-1beta production, reduces disease severity and the expression of inflammatory mediators in models of rheumatoid arthritis and skin inflammation.Epilepsy Phase 2 Discontinued
Product Categories/Family for VX-765 biochemical
References
1. Stack JH, et al. J Immunol. 2005 Aug 15; 175 (4):2630-4.
2. Wannamaker W, et al. J Pharmacol Exp Ther. 2007 May; 321 (2):509-16.
3. Bialer M, et al. Epilepsy Res. 2013 Jan; 103 (1):2-30.
4. Wang W, et al. Proc Natl Acad Sci U S A. 2016 Aug 23; 113 (34):9587-92.
2. Wannamaker W, et al. J Pharmacol Exp Ther. 2007 May; 321 (2):509-16.
3. Bialer M, et al. Epilepsy Res. 2013 Jan; 103 (1):2-30.
4. Wang W, et al. Proc Natl Acad Sci U S A. 2016 Aug 23; 113 (34):9587-92.
Similar Products
Product Notes
The VX-765 (Catalog #AAA3603835) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "VX-765, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
