Testing Data
(TSU-68 (SU6668) has significant antitumor activity against many types of tumor xenograft explants in athymic mice. TSU-68 (SU6668) inhibits angiogenesis through several mechanisms, including the induction of apoptosis in vascular endothelial cells and tumor cells, resulting in perturbing existing tumor vascular function and also inhibiting newly synthesis angiogenesis for the tumor growth. TSU-68 (SU6668) has the effect on blocking the tyrosine kinase phosphorylation of the receptors not only for VEGF but also for PDGF and bFGF, and inhibiting angiogenesis. Studies using in vivo experimental models of cancers such as colon cancer have reported that TSU-68 (SU6668) has the effect on inhibiting tumor proliferation and metastasis through the inhibition of tumor angiogenesis. In vitro TSU-68 (SU6668) does not influence the proliferation of ovarian cancer cells. The administration of TSU-68 (SU6668) does not influence the concentration of VEGF or PDGF in the ascetic fi‚uid of mice with peritoneal dissemination of ovarian cancer. TSU-68 (SU6668) does not act directly on VEGF or PDGF, but binds to their receptors, thereby inhibiting their phosphorylation. [1][2])
TSU-68, inhibitor
TSU-68 (SU6668)
Synonyms
TSU-68; TSU-68 (SU6668); inhibitor
Solubility
DMSO >=62 mg/mL - Water <1 mg/mL - Ethanol <1 mg/mL
Formula
C18H18N2O3
CAS Number
252916-29-3
Preparation and Storage
Stable for; 2 years at -20 degree C Powder
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
Testing Data
(TSU-68 (SU6668) has significant antitumor activity against many types of tumor xenograft explants in athymic mice. TSU-68 (SU6668) inhibits angiogenesis through several mechanisms, including the induction of apoptosis in vascular endothelial cells and tumor cells, resulting in perturbing existing tumor vascular function and also inhibiting newly synthesis angiogenesis for the tumor growth. TSU-68 (SU6668) has the effect on blocking the tyrosine kinase phosphorylation of the receptors not only for VEGF but also for PDGF and bFGF, and inhibiting angiogenesis. Studies using in vivo experimental models of cancers such as colon cancer have reported that TSU-68 (SU6668) has the effect on inhibiting tumor proliferation and metastasis through the inhibition of tumor angiogenesis. In vitro TSU-68 (SU6668) does not influence the proliferation of ovarian cancer cells. The administration of TSU-68 (SU6668) does not influence the concentration of VEGF or PDGF in the ascetic fi‚uid of mice with peritoneal dissemination of ovarian cancer. TSU-68 (SU6668) does not act directly on VEGF or PDGF, but binds to their receptors, thereby inhibiting their phosphorylation. [1][2])
Testing Data
(TSU-68 (SU6668) has significant antitumor activity against many types of tumor xenograft explants in athymic mice. TSU-68 (SU6668) inhibits angiogenesis through several mechanisms, including the induction of apoptosis in vascular endothelial cells and tumor cells, resulting in perturbing existing tumor vascular function and also inhibiting newly synthesis angiogenesis for the tumor growth. TSU-68 (SU6668) has the effect on blocking the tyrosine kinase phosphorylation of the receptors not only for VEGF but also for PDGF and bFGF, and inhibiting angiogenesis. Studies using in vivo experimental models of cancers such as colon cancer have reported that TSU-68 (SU6668) has the effect on inhibiting tumor proliferation and metastasis through the inhibition of tumor angiogenesis. In vitro TSU-68 (SU6668) does not influence the proliferation of ovarian cancer cells. The administration of TSU-68 (SU6668) does not influence the concentration of VEGF or PDGF in the ascetic fi‚uid of mice with peritoneal dissemination of ovarian cancer. TSU-68 (SU6668) does not act directly on VEGF or PDGF, but binds to their receptors, thereby inhibiting their phosphorylation. [1][2])
Related Product Information for TSU-68, inhibitor
TSU-68 (SU6668) has significant antitumor activity against many types of tumor xenograft explants in athymic mice. TSU-68 (SU6668) inhibits angiogenesis through several mechanisms, including the induction of apoptosis in vascular endothelial cells and tumor cells, resulting in perturbing existing tumor vascular function and also inhibiting newly synthesis angiogenesis for the tumor growth. TSU-68 (SU6668) has the effect on blocking the tyrosine kinase phosphorylation of the receptors not only for VEGF but also for PDGF and bFGF, and inhibiting angiogenesis. Studies using in vivo experimental models of cancers such as colon cancer have reported that TSU-68 (SU6668) has the effect on inhibiting tumor proliferation and metastasis through the inhibition of tumor angiogenesis. In vitro TSU-68 (SU6668) does not influence the proliferation of ovarian cancer cells. The administration of TSU-68 (SU6668) does not influence the concentration of VEGF or PDGF in the ascetic ?uid of mice with peritoneal dissemination of ovarian cancer. TSU-68 (SU6668) does not act directly on VEGF or PDGF, but binds to their receptors, thereby inhibiting their phosphorylation. [1][2]
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Product Notes
The TSU-68 (Catalog #AAA8506250) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TSU-68, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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