Structure
TD-139, Inhibitor
TD-139
Purity
>98% (HPLC)
Synonyms
TD-139; TD139; TD 139; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 1mg/mL (Need ultrasonic)
H2O: <5mg/mL
Ethanol: 0.1mg/mL (Need ultrasonic and warming)
H2O: <5mg/mL
Ethanol: 0.1mg/mL (Need ultrasonic and warming)
Target
Galectin
Receptor
galectin-3
Chemical Name
beta-D-Galactopyranoside, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1, 2, 3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1, 2, 3-triazol-1-yl]-1-thio
SMILES
O[C@H]([C@@H](N1N=NC(C2=CC=CC(F)=C2)=C1)[C@H]([C@@H](CO)O3)O)[C@@H]3S[C@H]4[C@@H]([C@@H](N5N=NC(C6=CC=CC(F)=C6)=C5)[C@H]([C@@H](CO)O4)O)O
Molecular Formula
C28H30F2N6O8S
CAS Number
1450824-22-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for TD-139, inhibitor
TD-139 (TD139) is a highly potent, selecitve inhibitor of Galectin-3 (Gal-3) carbohydrate binding domain with Ki of 14nM; reduces TGF-beta1-induced beta-catenin translocation to the nucleus, blocks beta-catenin phosphorylation in vitro and in vivo; attenuates the late-stage progression of lung fibrosis in murine models; attenuates liver injury and milder infiltration of IFNgamma- and IL-17- and -4-producing CD4 (+) T cells, increases IL-10-producing CD4 (+) T cells and F4/80 (+) CD206 (+) alternatively activated macrophages and prevents the apoptosis of liver-infiltrating MNCs in WT C57BL/6 mice. Cystic Fibrosis, Phase 2 Clinical
Product Categories/Family for TD-139, inhibitor
References
1. Mackinnon AC, et al. Am J Respir Crit Care Med. 2012 Mar 1; 185 (5):537-46.
2. Volarevic V, et al. Hepatology. 2012 Jun; 55 (6):1954-64.
3. Volarevic V, et al. Eur J Immunol. 2015 Feb; 45 (2):531-43.
2. Volarevic V, et al. Hepatology. 2012 Jun; 55 (6):1954-64.
3. Volarevic V, et al. Eur J Immunol. 2015 Feb; 45 (2):531-43.
Similar Products
Product Notes
The TD-139 (Catalog #AAA3601938) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TD-139, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
