Structure
TAK-438 free base, Inhibitor
TAK-438 free base
Purity
>98% (HPLC)
Synonyms
TAK-438 free base; Vonoprazan; TAK438 free base; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=33mg/mL
Target
Proton Pump
Receptor
Proton Pump
Chemical Name
1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)
SMILES
CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3
Molecular Formula
C17H16FN3O2S
CAS Number
881681-00-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for TAK-438 free base, inhibitor
A novel potent, oral potassium-competitive acid blocker (P-CAB) that potently inhibits H+, K+-ATPase with IC50 of 19nM; completely inhibits basal and 2-deoxy-d-glucose-stimulated gastric acid secretion in rats (4mg/kg, p. O.); increases the pH of gastric perfusate to a higher value, and sustains longer than those of lansoprazole or SCH28080; a clinical candidate for the treatment of gastroesophageal reflux disease (GERD), peptic ulcer, and other acid-related diseases. Ulcer Phase 3 Clinical
Product Categories/Family for TAK-438 free base, inhibitor
References
1. Arikawa Y, et al. J Med Chem. 2012 May 10; 55 (9):4446-56.
2. Hori Y, et al. J Pharmacol Exp Ther. 2010 Oct; 335 (1):231-8.
3. Shin JM, et al. J Pharmacol Exp Ther. 2011 Nov; 339 (2):412-20.
2. Hori Y, et al. J Pharmacol Exp Ther. 2010 Oct; 335 (1):231-8.
3. Shin JM, et al. J Pharmacol Exp Ther. 2011 Nov; 339 (2):412-20.
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Product Notes
The TAK-438 free base (Catalog #AAA3606388) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TAK-438 free base, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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