Chemical Structure

Tacrolimus hydrate, Inhibitor

Tacrolimus hydrate

Purity

0.992

Synonyms

Tacrolimus hydrate; FK-506; FK 506; Prograf; LCP-Tacro; FR900506; FR 900506; inhibitor

Ordering
Cat. Num. AAA5764784 For Research Use Only!

Purity/Purification

0.992

Form/Format

Solid

Solubility

DMSO: 100mg/mL (121.65mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

SMILES

O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC=C)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O.O

Formula

C44H71NO13

CAS Number

109581-93-3

Preparation and Storage

Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).

Chemical Structure

Related Product Information for Tacrolimus hydrate, inhibitor

Tacrolimus hydrate is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties. It prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro and has strong immunosuppressive activity in vivo.

Product Categories/Family for Tacrolimus hydrate, inhibitor

Autophagy; Metabolism; Microbiology/Virology; Antibacterial

References

Dodi PL. Immune-mediated keratoconjunctivitis sicca in dogs: current perspectives on management. Vet Med (Auckl). 2015 Oct 30;6:341-347. doi: 10.2147/VMRR.S66705. eCollection 2015. Review. PubMed PMID: 30101119; PubMed Central PMCID: PMC6067592.
Kumar A, Singh N. Calcineurin Inhibition and Protein Kinase A Activation Limits Cognitive Dysfunction and Histopathological Damage in a Model of Dementia of the Alzheimer's Type. Curr Neurovasc Res. 2018 Aug 13. doi: 10.2174/1567202615666180813125125. [Epub ahead of print] PubMed PMID: 30101704.
Shin MH, Song GW, Lee SG, et al. Once-daily, prolonged-release tacrolimus versus twice-daily, immediate-release tacrolimus in de novo living-donor liver transplantation: a Phase 4, randomized, open-label, comparative, single-center study. Clin Transplant. 2018 Aug 11:e13376. doi: 10.1111/ctr.13376. [Epub ahead of print] PubMed PMID: 30098071.
Liu YJ, Fan H, Zhen WW, Yu X, Chen JT, Wang CD. Pooled analysis of the comparative efficacy between tacrolimus and infliximab for ulcerative colitis. Medicine (Baltimore). 2018 Aug;97(32):e11440. doi: 10.1097/MD.0000000000011440. PubMed PMID: 30095612.

Similar Products

Tacrolimus Biochemical

Host: n/a

Reactivity: n/a

Apps: n/a

Product Notes

The Tacrolimus hydrate (Catalog #AAA5764784) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Tacrolimus hydrate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Tacrolimus hydrate, Inhibitor