Structure
SRS11-92, Inhibitor
SRS11-92
Purity
>98% (HPLC)
Synonyms
SRS11-92; SRS 11-92; inhibitor
Purity/Purification
>98% (HPLC)
Target
Ferroptosis
Receptor
Ferroptosis
Chemical Name
4-(cyclohexylamino)-3-[(phenylmethyl)amino]-benzoic acid, ethyl ester
SMILES
CCOC(=O)C1=CC(=C(C=C1)NC2CCCCC2)NCC3=CC=CC=C3
Molecular Formula
C22H28N2O2
CAS Number
1467047-25-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SRS11-92, inhibitor
SRS11-92 (SRS 11-92) is a small molecule inhibitor of Ferroptosis and a derivative of Ferrostatin-1 (Fer-1), inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells with EC50 of 6nM; inhibits iron-induced cell death in isolated mouse kidney proximal tubules at 2uM, and fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100nM; also increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington's disease in a concentration-dependent manner.
Product Categories/Family for SRS11-92, inhibitor
References
1. Cotticellimg, et al. J Pharmacol Exp Ther. 2019 Jan 11. pii: jpet.118.252759.
2. Linkermann A, et al. Proc Natl Acad Sci U S A. 2014 Nov 25; 111 (47):16836-41.
2. Linkermann A, et al. Proc Natl Acad Sci U S A. 2014 Nov 25; 111 (47):16836-41.
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Product Notes
The SRS11-92 (Catalog #AAA3601998) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SRS11-92, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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