Western Blot (WB)
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Mouse ITI H4 Monoclonal Antibody | anti-ITI H4 antibody
ITI H4 antibody
Gene Names
ITIH4; H4P; IHRP; GP120; PK120; ITIHL1; PK-120; ITI-HC4
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
ITI H4 antibody was purified by ammonium sulfate precipitation
Synonyms
ITI H4; Monoclonal Antibody; ITI H4 antibody; Monoclonal ITI H4; Anti-ITI H4; ITIH4; inter-alpha-trypsin inhibitor heavy chain family; member 4; BOS_20961; GP120; H4P; IHRP; inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein); inter-alpha-inhibitor H4 heavy chain; inter-alpha-inhibitor heavy chain 4; inter-alpha-trypsin inhibitor family heavy chain-related protein; inter alpha-trypsin inhibitor; heavy chain 4; inter-alpha-trypsin inhibitor heavy chain H4; inter-alpha-trypsin inhibitor; heavy chain-like; 1; Itih-4; ITI-HC4; ITI heavy chain H4; ITIHL1; major acute phase protein; MAP; PK120; PK-120; plasma kallikrein-sensitive glycoprotein 120; PRO1851; RP23-205O23.1; anti-ITI H4 antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
45A12
Purity/Purification
ITI H4 antibody was purified by ammonium sulfate precipitation
Form/Format
Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
Sequence Length
900
Applicable Applications for anti-ITI H4 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes
WB: 1: 2000
Biological Significance
The inter-alpha-trypsin inhibitor (ITI) family, a typical and classical example for protein-glycosaminoglycanprotein (PGP) complexes, occurs constitutively in plasma at relatively high concentrations and is a result of alternate combinations of three kinds of heavy chains with a common light chain, the bikunin proteoglycan. Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family; it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology.
Cross-Reactivity
Human
Immunogen
ITI H4 antibody was raised in Mouse using a protein purified from Human plasma as the immunogen
Preparation and Storage
Aliquot and store for 1 year at -20 degree C, avoid freeze/thaw cycles
Western Blot (WB)
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Western Blot (WB)
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Related Product Information for anti-ITI H4 antibody
Mouse monoclonal ITI H4 antibody
Product Categories/Family for anti-ITI H4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
93,852 Da
NCBI Official Full Name
inter-alpha-trypsin inhibitor heavy chain H4 isoform 2
NCBI Official Synonym Full Names
inter-alpha-trypsin inhibitor heavy chain family, member 4
NCBI Official Symbol
ITIH4
NCBI Official Synonym Symbols
H4P; IHRP; GP120; PK120; ITIHL1; PK-120; ITI-HC4
NCBI Protein Information
inter-alpha-trypsin inhibitor heavy chain H4
UniProt Protein Name
Inter-alpha-trypsin inhibitor heavy chain H4
UniProt Gene Name
ITIH4
UniProt Synonym Gene Names
IHRP; ITIHL1; PK120; ITI heavy chain H4; ITI-HC4; Inter-alpha-inhibitor heavy chain 4; IHRP; Gp120; PK-120
UniProt Entry Name
ITIH4_HUMAN
NCBI Description
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Description
ITIH4: May be involved in acute phase reactions. Belongs to the ITIH family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component: cytoplasm; extracellular region; plasma membrane
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; endopeptidase inhibitor activity
Biological Process: response to cytokine stimulus; acute-phase response; hyaluronan metabolic process
Disease: Hypercholesterolemia, Familial
Research Articles on ITI H4
Similar Products
Product Notes
The ITI H4 itih4 (Catalog #AAA832416) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's ITI H4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) Paraffin. WB: 1: 2000. Researchers should empirically determine the suitability of the ITI H4 itih4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ITI H4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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