Structure
SGI-1776, Inhibitor
SGI-1776
Purity
>98% (HPLC)
Synonyms
SGI-1776; SGI 1776; SGI1776; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Pim
Receptor
FLT3; Pim1; Pim2; Pim3
Chemical Name
Imidazo[1, 2-b]pyridazin-6-amine, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]
SMILES
FC(F)(F)OC1=CC=C(C2=CN=C3C=CC(NCC4CCN(C)CC4)=NN32)C=C1
Molecular Formula
C20H22F3N5O
CAS Number
1025065-69-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SGI-1776, inhibitor
SGI-1776 is a potent, selective, orally active Pim kinase inhibitor with IC50 of 7, 363 and 69nM for Pim1, Pim2 and Pim3, respectively; exhibits promising selectivity against a panel of >300 kinases, shows inhibitory activity against two other kinases: Flt-3 (IC50=44nM) and Haspin (IC50=34nM); reduces cell viability of androgen-independent prostate cancer cell lines with IC50 of 2-4uM, causes cell cycle arrest and caspase-dependent apoptosis in prostate cancer cells, marginally sensitizes prostate cancer cells to taxane-based therapeutics by inhibiting MDR1 activity and inducing apoptosis; shows efficacy in xenograft model bearing MV-4-11 tumors. Prostate Cancer Phase 1 Clinical
Product Categories/Family for SGI-1776, inhibitor
References
1. Chen LS, et al. Blood. 2009 Nov 5; 114 (19):4150-7.
2. Chen LS, et al. Blood. 2011 Jul 21; 118 (3):693-702.
3. Chang M, et al. Mol Cancer Ther. 2010 Sep; 9 (9):2478-87.
4. Mumenthaler SM, et al. Mol Cancer Ther. 2009 Oct; 8 (10):2882-93.
2. Chen LS, et al. Blood. 2011 Jul 21; 118 (3):693-702.
3. Chang M, et al. Mol Cancer Ther. 2010 Sep; 9 (9):2478-87.
4. Mumenthaler SM, et al. Mol Cancer Ther. 2009 Oct; 8 (10):2882-93.
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Product Notes
The SGI-1776 (Catalog #AAA3600114) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SGI-1776, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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