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SEL120-34A HCl, Inhibitor | SEL120-34A, inhibitor

SEL120-34A HCl

Purity
98.00%
Synonyms
SEL120-34A HCl; SEL120-34A; inhibitor
Ordering
For Research Use Only!
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 62.5mg/mL Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C15H18Br2N4.xHCl
SMILES
Cl.Cc1c(Br)c(Br)c2CCCn3c(nc1c23)N1CCNCC1
CAS Number
1609452-30-3
Target & IC50
CDK8/CycC: ic50 4.4nM
CDK19/CycC: ic50 10.4nM
CDK9/cycT: ic50 1070nM
In Vitro
The growth of tumor in mice bearing MV4-11 cancer cells inhibited by SEL120-34A (30, 60mg/kg, p.o.), and also arrests the growth of KG-1-derived tumors at 30mg/kg via oral administration.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Related Product Information for SEL120-34A, inhibitor
SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4nM and 10.4nM, respectively), with antitumor activity.
Product Categories/Family for SEL120-34A, inhibitor
References
Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8(20):33779-33795.

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Product Notes

The SEL120-34A (Catalog #AAA5752892) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SEL120-34A HCl, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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