Salinomycin sodium salt, Inhibitor

Salinomycin sodium salt

Cat. Num. AAA5764468

• Purity: 100.00%
• Synonyms: Salinomycin sodium salt; Salinomycin sodium; inhibitor

• Purity/Purification: 100.00%
• Form/Format: Solid. Powder

• Solubility: DMSO: 12mg/mL (15.53mM); (<1mg/ml refers to the product slightly soluble or insoluble)
• Formula: C42H65NaO11
• SMILES: [H][C@]1([C@](C)(CC2)O[C@]32[C@](O)C=C[C@]4(O[C@]([H])([C@@H](CC)C([C@@H](C)[C@@H](O)[C@](C)[C@]5([H])O[C@]([C@@H](CC)C([O-])=O)([H])CC[C@@H]5C)=O)[C@@H](C)C[C@]4C)O3)CC[C@@](CC)(O)[C@](C)O1.[Na+]
• CAS Number: 55721-31-8
• Cell Research: Briefly, HUVECs (6,000cells/well) are seeded in 96-well culture plates for 24 hours and incubated with different concentrations of Salinomycin. In the preliminary experiments, Salinomycin treatment, for 12, 24, 48 and 72 h shows time-dependent effects on cell growth inhibition. However, treatment, for 48 h is the optimal time and is selected for further mechanism evaluation. After Salinomycin treatment, for 48 hours, 20uL/well of MTT solution (5mg/mL) is added and incubated for 5 hours. The medium is aspirated and replaced with 200uL/well of DMSO to dissolve the formazan Salinomycint formed. The color intensity of the formazan solution is measured at 570nM by a microplate spectrophotometer. The cell viability is expressed as% of the control (as 100%) [1].
• In Vitro: Salinomycin (5 and 10mg/kg) significantly suppresses the average tumor volume and tumor weight. Salinomycin hinders the U251 human glioma cell growth in vivo via inhibition of angiogenesis with the involvement of AKT and FAK dephosphorylation [1]. Salinomycin (0.5mg/kg b.wt.) enhances the mean survival time of the tumor-bearing Swiss albino mice [2].
• Preparation and Storage: Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent

Related Product Information for Salinomycin sodium salt, inhibitor

Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/beta-catenin signaling.

Product Categories/Family for Salinomycin sodium salt, inhibitor

Cytoskeletal Signaling; Wnt/beta-catenin

References

Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7.
Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7.
Zhou J, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactiveoxygen species. Toxicol Lett. 2013 Oct 24;222(2):139-45.
Zhou J, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactiveoxygen species. Toxicol Lett. 2013 Oct 24;222(2):139-45.
Klose J, et al. Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model. PLoS One. 2019 Feb 14;14(2):e0211916.
Klose J, et al. Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model. PLoS One. 2019 Feb 14;14(2):e0211916.
Wang F, et al. Salinomycin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells In Vitro and In Vivo. PLoS One. 2012; 7(12): e50638.
Wang F, et al. Salinomycin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells In Vitro and In Vivo. PLoS One. 2012; 7(12): e50638.