Structure
PKM2 inhibitor
PKM2 inhibitor
Purity
>98% (HPLC)
Synonyms
PKM2 inhibitor; MDK4882; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 5.56mg/mL (16.09mM)
H2O: <0.1mg/mL
H2O: <0.1mg/mL
Target
Other Targets
Receptor
PKM1; PKM2
Chemical Name
(3-methyl-1, 4-dioxo-1, 4-dihydronaphthalen-2-yl)methyl piperidine-1-carbodithioate
SMILES
CC1=C(C(=O)c2ccccc2C1=O)CSC(=S)N1CCCCC1
Molecular Formula
C18H19NO2S2
CAS Number
94164-88-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PKM2 inhibitor, inhibitor
MDK4882, also known as PKM2 inhibitor or compound 3k, is a PKM2 inhibitor. MDK4882 was first described in Eur J Med Chem. 2017; 138:343-352. Currently there is no formal name. We temporarily name it MDK4882 for the convenience of communication, in which the last 4 digit of CAS# is used. MDK4882 displayed more potent PKM2 inhibitory activity than the reported optimal PKM2 inhibitor shikonin. MDK4882 also showed nanomolar antiproliferative activity toward a series of cancer cell lines with high expression of PKM2 including HCT116, Hela and H1299 with IC50 values ranging from 0.18 to 1.56uM. MDK4882 exhibited more cytotoxicity on cancer cells than normal cells.
Product Categories/Family for PKM2 inhibitor, inhibitor
References
1. Ning X, et al. Eur J Med Chem. 2017 Sep 29; 138:343-352.
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Product Notes
The PKM2 inhibitor (Catalog #AAA3609268) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PKM2 inhibitor, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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