Structure
GSK J1, Inhibitor
GSK J1
Purity
>98% (HPLC)
Synonyms
GSK J1; GSKJ1; GSKJ 1; GSKJ-1; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=33mg/mL (84.73mM)
Target
Other Targets
Receptor
JMJD3 (KDM6B); UTX (KDM6A)
Chemical Name
3-((2-(pyridin-2-yl)-6-(1, 2, 4, 5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid
SMILES
OC(=O)CCNC1=CC(=NC(=N1)C1=CC=CC=N1)N1CCC2=C(CC1)C=CC=C2
Molecular Formula
C22H23N5O2
CAS Number
1373422-53-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GSK J1, inhibitor
GSKJ1 is a selective and potent histone demethylase inhibitor (GSK-J1) that has significant activity (IC50 60nM for human JmjD3) in vitro and in cells using an ester derivative (GSK-J4: 1uM 100uM for human JmjD3) and thus can be used as control for target effects in vitro, and as ester derivative (GSK-J5) in cells. Recent data has shown that GSK-J1 also shows some activity (IC50 950nM for Jarid1b, IC50 1.76uM for Jarid1c) against H3K4me3/2/1 demethylases.
Product Categories/Family for GSK J1, inhibitor
Similar Products
Product Notes
The GSK J1 (Catalog #AAA3607976) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GSK J1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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