Structure
Pitstop 2, Inhibitor
Pitstop 2
Purity
>98% (HPLC)
Synonyms
Pitstop 2; Pitstop-2; Pitstop2; inhibitor
Purity/Purification
>98% (HPLC)
Target
Clathrin
Receptor
Clathrin
Chemical Name
(Z)-N-(5-(4-bromobenzylidene)-4-oxo-4, 5-dihydrothiazol-2-yl)naphthalene-1-sulfonamide
SMILES
C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)N=C3NC(=O)C(=CC4=CC=C(C=C4)Br)S3
Molecular Formula
C20H13BrN2O3S2
CAS Number
1419093-54-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Pitstop 2, inhibitor
A small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis; inhibits endocytosis of transferrin receptor, a CDE cargo protein, but not affect endocytosis of shiga toxin; traps HeLa cells in metaphase through loss of mitotic spindle integrity and activation of the spindle assembly checkpoint, a useful tool for investigating clathrin spindle dynamics.
Product Categories/Family for Pitstop 2, inhibitor
References
1. Dutta D, et al. PLoS One. 2012; 7 (9):e45799.
2. Smith CM, et al. Mol Cancer. 2013 Jan 17; 12:4.
3. Liashkovich I, et al. Sci Rep. 2015 May 6; 5:9994.
4. Willox AK, et al. Biol Open. 2014 Apr 4; 3 (5):326-31.
2. Smith CM, et al. Mol Cancer. 2013 Jan 17; 12:4.
3. Liashkovich I, et al. Sci Rep. 2015 May 6; 5:9994.
4. Willox AK, et al. Biol Open. 2014 Apr 4; 3 (5):326-31.
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Product Notes
The Pitstop 2 (Catalog #AAA3601752) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Pitstop 2, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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