Structure
Dual BET-Kinase inhibitor 3, Inhibitor
Dual BET-Kinase inhibitor 3
Purity
>98% (HPLC)
Synonyms
Dual BET-Kinase inhibitor 3; BRD4-Kinases-IN-3; BRD4 Kinases IN 3; BRD4KinasesIN3; BRD4 kinases inhibitor 3; inhibitor
Purity/Purification
>98% (HPLC)
Target
Bromodomain
Receptor
Bromodomain
Chemical Name
N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)phenyl)-2-methylpropane-2-sulfonamide
SMILES
CC(S(=O)(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C)CC4)C(F)=C3)=NC=C2C)=C1)=O)(C)C
Molecular Formula
C26H34FN7O2S
CAS Number
1877286-69-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Dual BET-Kinase inhibitor 3, inhibitor
A potent, dual BET bromodomain-kinase inhibitor with IC50 of 34, 1.1 and 1.1nM for BRD4 BD1, JAK2 and FLT-3, respectively; also significantly inhibits NTRK3 (IC50=5nM), ROS1 (IC50=11nM), PDGFRbeta (IC50=16nM) and FGFR1 (IC50=43nM), shows equal activity against the first and second bromodomains of BRD4 and shows only slightly reduced activity against BRDT-1; inhibits cell growth of MM and AML cell lines with IC50 of
Product Categories/Family for Dual BET-Kinase inhibitor 3, inhibitor
References
1. Ember SW, et al. Mol Cancer Ther. 2017 Jun; 16 (6):1054-1067.
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Product Notes
The Dual BET-Kinase inhibitor 3 (Catalog #AAA3602912) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Dual BET-Kinase inhibitor 3, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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