Rabbit FOXC2 Polyclonal Antibody | anti-FOXC2 antibody

FOXC2 Rabbit Polyclonal

Cat. Num. AAA769423

• Gene Names: FOXC2; LD; MFH1; MFH-1; FKHL14
• Reactivity: Human, Rat, Mouse
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: FOXC2; Polyclonal Antibody; FOXC2 Rabbit Polyclonal; anti-FOXC2 antibody

• Host: Rabbit
• Reactivity: Human, Rat, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 501

• Applicable Applications for anti-FOXC2 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Forkhead box C2 (MFH-1, mesenchyme forkhead 1)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(A375 cells were subjected to SDS PAGE followed by western blot with MBS769423 (FOXC2 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 4885237
• NCBI GeneID: 2303
• NCBI Accession #: NP_005242.1
• NCBI GenBank Nucleotide #: NM_005251.2
• Molecular Weight: 53,719 Da
• NCBI Official Full Name: forkhead box protein C2
• NCBI Official Synonym Full Names: forkhead box C2
• NCBI Official Symbol: FOXC2
• NCBI Official Synonym Symbols: LD; MFH1; MFH-1; FKHL14
• NCBI Protein Information: forkhead box protein C2
• UniProt Protein Name: Forkhead box protein C2
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXC2
• UniProt Synonym Gene Names: FKHL14; MFH1; MFH-1 protein
• UniProt Entry Name: FOXC2_HUMAN

NCBI Description

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]

Uniprot Description

FOXC2: Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. Defects in FOXC2 are the cause of lymphedema hereditary type 2 (LMPH2); also known as Meige lymphedema. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections, and physical impairment. Defects in FOXC2 are a cause of lymphedema-yellow nails (LYYN). LYYN is characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities. Defects in FOXC2 are a cause of lymphedema-distichiasis (LYD). LYD is characterized by primary limb lymphedema usually starting at puberty (but in some cases later or at birth) and associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices).

Protein type: Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: nucleus

Molecular Function: chromatin DNA binding; identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: heart development; insulin receptor signaling pathway; lymphangiogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell adhesion mediated by integrin; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to hormone stimulus

Disease: Lymphedema-distichiasis Syndrome