Structure
PFE-360, Inhibitor
PFE-360
Purity
>98% (HPLC)
Synonyms
PFE-360; PFE360; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 10.42mg/mL (33.79mM)
Target
LRRK2
Receptor
LRRK2
Chemical Name
1-methyl-4-(4-morpholino-7H-pyrrolo[2, 3-d]pyrimidin-5-yl)pyrrole-2-carbonitrile
SMILES
N#CC1=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=CN1C
Molecular Formula
C16H16N6O
CAS Number
1527475-61-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PFE-360, inhibitor
PFE-360 is a novel potent, selective, brain-penetrating LRRK2 inhibitor with IC50 of 3nM; induces a morphological kidney phenotype resembling that of the LRRK2 ko rats, whereas no effects in the lung; PFE-360 treatment induces morphological changes characterised by darkened kidneys and progressive accumulation of hyaline droplets in the renal proximal tubular epithelium, the estimated PFE-360 unbound plasma concentration off 10-fold the IC50 (30nM) to achieve full peripheral LRRK2 inhibition.
Product Categories/Family for PFE-360, inhibitor
References
1. Fuji RN, et al. Sci Transl Med. 2015 Feb 4; 7 (273):273ra15.
2. Andersen MA, et al. Toxicology. 2018 Feb 15; 395:15-22.
2. Andersen MA, et al. Toxicology. 2018 Feb 15; 395:15-22.
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Product Notes
The PFE-360 (Catalog #AAA3602139) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PFE-360, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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