Testing Data
PF-2341066, inhibitor
PF-2341066 (Crizotinib)
Purity
>99%
Synonyms
PF-2341066; PF-2341066 (Crizotinib); inhibitor
Purity/Purification
>99%
Solubility
DMSO >=23mg/mL - Water <1mg/mL - Ethanol >=8mg/mL
Formula
C21H22Cl2FN5O
CAS Number
877399-52-5
Preparation and Storage
Store at-20 degree C 2 years.
Testing Data
Testing Data
Related Product Information for PF-2341066, inhibitor
Inhibitor of the catalytic activity of c-Met kinase and the NPM-ALK(nucleophosmin-anaplastic lymphoma kinase) fusion protein.[1] A t(2; 5) chromosomal translocation resulting in expression of an oncogenic kinase fusion protein known as NPM-ALK has been implicated in the pathogenesis of anaplastic large-cell lymphoma (ALCL). [2] After incubation with Crizotinib (PF-02341066), cells were washed once with HBSS supplemented with 1 mmol/L Na3VO4 and protein lysates were generated. Subsequently, phosphorylation of ALK was assessed by a sandwich ELISA method using an immobilized anti-total-ALK antibody and an anti-phospho-ALK antibody (pY1604) as a detec ion antibody. Crizotinib (PF-02341066) inhibited NPM-ALKphosphorylation in Karpas299 or SU-DHL-1 ALCL cells (mean IC50 value=24 nM). Crizotinib (PF-02341066) potently inhibited cell proliferation, which was associated with G1-S-phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC50 values=30 nM) but not ALK-negative lymphoma cells. The induction of apoptosis was confirmed using terminal deoxyribonucleotide transferase-mediated nick-end labeling and Annexin V staining (IC50 values=25-50 nM). [3]
Product Categories/Family for PF-2341066, inhibitor
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Product Notes
The PF-2341066 (Catalog #AAA8506463) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PF-2341066, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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