Structure
Olmesartan, Inhibitor
Olmesartan
Purity
98.00%
Synonyms
Olmesartan; RNH 6270; CS 088; inhibitor
Purity/Purification
98.00%
Form/Format
Powder
Formula
C24H26N6O3
CAS
144689-24-7
Smiles
CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)C(C)(C)O
Receptor (IC50)
angiotensin II receptor
Solubility
DMSO: 55mg/mL (123.18mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Structure
Structure
Related Product Information for Olmesartan, inhibitor
Olmesartan is an Angiotensin II Type I receptor antagonist. Olmesartan is the active form of the antihypertensive drug olmesartan medoxomil,and has antihypertensive activity.
Product Categories/Family for Olmesartan, inhibitor
References
1. Haller H, Ito S, Izzo J L, et al. Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes[J]. New England Journal of Medicine, 2011, 364 (10):907-917.
2. Omboni S, Volpe M.Management of arterial hypertension with angiotensin receptor blockers: Current evidence and the role of olmesartan[1].Cardiovasc Ther. 2018 Dec;36 (6):e12471.
3. Bakhtiari E, et al. Synergistic, cytotoxic and apoptotic activities of olmesartan with NF-kappaB inhibitor against HeLa human cell line. Toxicol Mech Methods. 2015;25 (8):614-21.
4. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131 (3):190-7.
5. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang (1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67 (6):503-9.
2. Omboni S, Volpe M.Management of arterial hypertension with angiotensin receptor blockers: Current evidence and the role of olmesartan[1].Cardiovasc Ther. 2018 Dec;36 (6):e12471.
3. Bakhtiari E, et al. Synergistic, cytotoxic and apoptotic activities of olmesartan with NF-kappaB inhibitor against HeLa human cell line. Toxicol Mech Methods. 2015;25 (8):614-21.
4. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131 (3):190-7.
5. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang (1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67 (6):503-9.
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Product Notes
The Olmesartan (Catalog #AAA5752241) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Olmesartan, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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