Structure
OABK hydrochloride, Inhibitor | OABK, inhibitor
OABK hydrochloride
Purity
98.00%
Synonyms
OABK hydrochloride; OABK; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C14H20ClN5O4
SMILES
N[C@@H](CCCCNC(OCC1=CC=CC=C1N=[N+]=[N-])=O)C(O)=O.[H]Cl
CAS Number
1984862-48-7
Target & IC50
Others
In Vitro
Introducing OABK at position K206 inhibits FLuc enzymatic activity by restricting the access of adenosine triphosphate (ATP) to the active site until the enzyme is deprotected and activated through phosphine treatment, Through the site-specific incorporation of an ortho-azidobenzyloxycarbonyl lysine (OABK)A small-molecule switch for the activation of protein function. Genetically encoded OABK in conjunction with small-molecule activation allows for the conditional regulation of intracellular protein maturation. Deprotection causes the formation of lysine and when OABK is incorporated into a protein, the formation of the active wild-type protein. Incorporation of OABK (0.5mM) at position K85 of EGFP suppresses fluorophore formation until the native lysine is generated through small-molecule activation (the model is based on Protein Data Bank (PDB). The incorporation of OABK into FLuc blocks the luciferase activity in the absence of small-molecule activation, as determined by a Bright-Glo luciferase assay.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for OABK, inhibitor
OABK hydrochloride is a small-molecule switch. It also can be used to control protein activity.
References
Luo J, et al. Small-molecule control of protein function through Staudinger reduction. Nat Chem. 2016 Nov;8(11):1027-1034.
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Product Notes
The OABK (Catalog #AAA5755296) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "OABK hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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