Structure
MK-8245, Inhibitor
MK-8245
Purity
>98% (HPLC)
Synonyms
MK-8245; MK 8245; MK8245; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 19mg/mL
Target
SCD
Receptor
SCD1 (human); SCD1 (mouse); SCD1 (rat)
Chemical Name
2H-Tetrazole-2-acetic acid, 5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]
SMILES
OC(=O)CN1N=NC(=N1)C1=CC(=NO1)N1CCC(CC1)OC1=C(Br)C=CC(F)=C1
Molecular Formula
C17H16BrFN6O4
CAS Number
1030612-90-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MK-8245, inhibitor
MK-8245 is a potent, selective liver-targeted stearoyl-CoA desaturase (SCD) inhibitor with IC50 of 3, 3 and 1nM for rat, mouse and human SCD1 enzyme, respectively; displays highly selective over the delta-5 and delta-6 desaturases (IC50>100uM); has IC50 values of 68nM and 1066nM in Hum HepG2 and rat hepatocyte assays, demonstrates HepG2/hepatocyte ratio of 16:1; exhibits preclinical antidiabetic and antidyslipidemic efficacy in vivo, demonstrats maximal liver SCD inhibition while sparing inhibition in the skin and eye tissues associated with adverse events. Diabetes Phase 1 Discontinued
Product Categories/Family for MK-8245, inhibitor
References
1. Oballa RM, et al. J Med Chem. 2011 Jul 28; 54 (14):5082-96.
2. Landry F, et al. J Lipid Res. 2011 Aug; 52 (8):1494-9.
2. Landry F, et al. J Lipid Res. 2011 Aug; 52 (8):1494-9.
Similar Products
Product Notes
The MK-8245 (Catalog #AAA3600149) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MK-8245, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
