Structure
MAP3K14-IN-173, Inhibitor
MAP3K14-IN-173
Purity
>98% (HPLC)
Synonyms
MAP3K14-IN-173; MAP3K14 inhibitor; inhibitor
Purity/Purification
>98% (HPLC)
Target
MEK
Receptor
MEK
Chemical Name
(R)-5-(2-((5-cyano-2-methyl-4-(2-morpholinoethyl)phenyl)amino)pyrimidin-4-yl)-3-(hydroxymethyl)-3-methylindoline-7-carbonitrile
SMILES
N#CC1=CC(C2=NC(NC3=CC(C#N)=C(CCN4CCOCC4)C=C3C)=NC=C2)=CC5=C1NC[C@@]5(CO)C
Molecular Formula
C29H31N7O2
CAS Number
2113617-02-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MAP3K14-IN-173, inhibitor
A novel potent MAP3K14 kinase inhibitor with IC50 of 1.8nM (NIK autophosphorylation); inhibits p-IKKalpha levels of L363 (NIK translocated multiple myeloma) cells with IC50 of 1.3nM; exhibits antiproliferative activity on JJN-3 (NIK translocated) multiple myeloma cells (IC50=29nM).
Product Categories/Family for MAP3K14-IN-173, inhibitor
References
1. Kargbo RB, et al. ACS Med Chem Lett. 2017 Aug 17; 8 (9):908-910.
2. Patent WO2017125530 A1, compound example 173.
2. Patent WO2017125530 A1, compound example 173.
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Product Notes
The MAP3K14-IN-173 (Catalog #AAA3603357) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MAP3K14-IN-173, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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