Lucidenic acid B, Inhibitor
Lucidenic acid B
Purity
98.00%
Synonyms
Lucidenic acid B; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C27H38O7
SMILES
C[C@H](CCC(O)=O)[C@@H](CC1=O)[C@@](C)([C@@H]2O)[C@]1(C)C([C@H](C[C@@H](C1(C)C)[C@]3(C)CCC1=O)O)=C3C2=O
CAS Number
95311-95-8
Target & IC50
PARP
Bcl-2
Caspase
Bcl-2
Caspase
In Vitro
The effect of lucidenic acids (A, B, C, and N) isolated from a new G. lucidum (YK-02) on induction of cell apoptosis and the apoptotic pathway in HL-60 cells were investigated. The results demonstrated that lucidenic acids decreased cell population growth of HL-60 cells, assessed with the MTT assay. The cell cycle assay indicated that treatment of HL-60 cells with lucidenic acid A, C, and N caused cell cycle arrest in the G 1 phase. Lucidenic acid B (LAB) did not affect the cell cycle profile; however, it increased the number of early and late apoptotic cells but not necrotic cells. treatment of HL-60 cells with LAB caused loss of mitochondria membrane potential. Moreover, the ratio of expression levels of pro- and antiapoptotic Bcl-2 family members was changed by LAB treatment, LAB-induced apoptosis involved release of mitochondria cytochrome c and subsequently induced the activation of caspase-9 and caspase-3, which were followed by cleavage of poly(ADP-ribose) polymerase (PARP)[1]
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Lucidenic acid B, inhibitor
Lucidenic acid B shows antioxidative, and anti-invasive effects, it inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1. Lucidenic acid B also has chemopreventive potential, it induces apoptosis in human leukemia cells via a mitochondria-mediated pathway.
Product Categories/Family for Lucidenic acid B, inhibitor
References
Lucidenic acid B induces apoptosis in human leukemia cells via a mitochondria-mediated pathway.J Agric Food Chem. 2008 Jun 11;56(11):3973-80.
Lucidenic acid B induces apoptosis in human leukemia cells via a mitochondria-mediated pathway.J Agric Food Chem. 2008 Jun 11;56(11):3973-80.
The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain.Mol Nutr Food Res. 2007 Dec;51(12):1472-7.
Triterpene antioxidants from ganoderma lucidum.Phytother Res. 1999 Sep;13(6):529-31.
Lucidenic acid B induces apoptosis in human leukemia cells via a mitochondria-mediated pathway.J Agric Food Chem. 2008 Jun 11;56(11):3973-80.
The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain.Mol Nutr Food Res. 2007 Dec;51(12):1472-7.
Triterpene antioxidants from ganoderma lucidum.Phytother Res. 1999 Sep;13(6):529-31.
Similar Products
Product Notes
The Lucidenic acid B (Catalog #AAA5760599) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Lucidenic acid B, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
