Structure
LMT-28, Inhibitor
LMT-28
Purity
>98% (HPLC)
Synonyms
LMT-28; C25H32F3N5O4; inhibitor
Purity/Purification
>98% (HPLC)
Target
IL Receptor
Receptor
Interleukin Receptor
Chemical Name
(S)-3-((2S, 3S)-3-hydroxy-2-methyl-4-methylenenonanoyl)-4-isopropyloxazolidin-2-one
SMILES
O=C1OC[C@H](C(C)C)N1C([C@@H](C)[C@H](O)C(CCCCC)=C)=O
Molecular Formula
C17H29NO4
CAS Number
1239600-18-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for LMT-28, inhibitor
LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rbeta (gp130) with IC50 of 5.9uM (IL-6-induced luciferase activity), selectively inhibits IL-6-induced phosphorylation of STAT3, JAK2, and gp130; does not affect LIF-induced STAT3 activation and not inhibit IL-11 stimulation on HepG2 cells; binds directly and specifically to gp130, and thereby inhibits the interaction of gp130 with the IL-6/IL-6Ralpha complex; inhibits IL-6-induced proliferation of the human erythroleukemic cell line TF-1 with IC50 of 7.5uM; inhibits IL-6-induced TNF-alpha production, ameliorates the progression of pancreatitis in mice.
Product Categories/Family for LMT-28, inhibitor
References
1. Hong SS, et al. J Immunol. 2015 Jul 1; 195 (1):237-45.
2. Armstead WM, et al. Transl Stroke Res. 2018 Feb 23. doi: 10.1007/s12975-018-0617-z.
2. Armstead WM, et al. Transl Stroke Res. 2018 Feb 23. doi: 10.1007/s12975-018-0617-z.
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Product Notes
The LMT-28 (Catalog #AAA3600966) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LMT-28, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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