Structure
MRT 199665, Inhibitor
MRT 199665
Purity
>98% (HPLC)
Synonyms
MRT 199665; MRT199665; inhibitor
Purity/Purification
>98% (HPLC)
Target
SIK
Receptor
SIK
Chemical Name
7-[(1S)-4-Hydroxy-2, 3-dihydro-1H-inden-1-yl]-5, 5-dimethyl-2-(methylsulfonyl)-5, 7-dihydro-6H-pyrrolo[2, 3-d]pyrimidin-6-one
SMILES
O=C1C(C)(C)C2=CN=C(S(=O)(C)=O)N=C2N1[C@H]3CCC4=C3C=CC=C4O
Molecular Formula
C18H19N3O4S
CAS Number
1456858-57-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MRT 199665, inhibitor
MRT 199665 is a potent salt-inducible kinases (SIKs) inhibitor with IC50 of 110, 12, 43nM for SIK1, 2, 3 respectively; also inhibits AMPKalpha1/alpha2 (both IC50=10nM), MARK1/2/3/4 (both IC50=2nM), NUAK1/2 (IC50=3/120nM), and MELK (IC50=29nM); elevates IL-10 production by inducing the dephosphorylation of CREB-regulated transcriptional coactivator 3 (CRTC3), increases LPS-stimulated IL-10 production and greatly suppressed proinflammatory cytokine secretion (IL-6, IL-12, and TNF) in macrophages.
Product Categories/Family for MRT 199665, inhibitor
References
1. Clark K, et al. Proc Natl Acad Sci U S A. 2012 Oct 16; 109 (42):16986-91.
2. Darling NJ, et al. Biochem J. 2017 Feb 15; 474 (4):521-537.
3. Huang HT, et al. Elife. 2017 Sep 19; 6. pii: e26693.
2. Darling NJ, et al. Biochem J. 2017 Feb 15; 474 (4):521-537.
3. Huang HT, et al. Elife. 2017 Sep 19; 6. pii: e26693.
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Product Notes
The MRT 199665 (Catalog #AAA3601973) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MRT 199665, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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