Structure

Lasmiditan hydrochloride, Inhibitor

Lasmiditan hydrochloride

Purity

99.27%

Synonyms

Lasmiditan hydrochloride; LY 573144 hydrochloride; COL-144 hydrochloride; inhibitor

Ordering
Cat. Num. AAA5759202 For Research Use Only!

Purity/Purification

99.27%

Form/Format

Solid. Powder

Solubility

DMSO: 28mg/mL (67.66mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C19H19ClF3N3O2

SMILES

Cl.CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2c(F)cc(F)cc2F)n1

CAS Number

613677-28-4

Target & IC50

5-HT(1F) receptor: ic50 2.21uM (K1)

In Vitro

Lasmiditan, a novel serotonin1F receptor agonist, showed specific affinity in vitro for the receptor without any vasoconstrictive action and inhibited markers associated with electrical stimulation of trigeminal ganglion in migraine animal models[1].

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Structure

Related Product Information for Lasmiditan hydrochloride, inhibitor

Lasmiditan hydrochloride is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1:2.21uM)

Product Categories/Family for Lasmiditan hydrochloride, inhibitor

GPCR/G Protein; 5-HT Receptor; Neuroscience

References

Matilde Capi, Fernando de Andres, Luana Lionetto. Lasmiditan for the treatment,of Migraine.Expert Opin Investig Drugs. 2017 Feb;26(2):227-234.
Matilde Capi, Fernando de Andres, Luana Lionetto. Lasmiditan for the treatment,of Migraine.Expert Opin Investig Drugs. 2017 Feb;26(2):227-234.
Bernice Kuca, Stephen D Silberstein, Linda Wietecha.Lasmiditan Is an Effective Acute treatment, for Migraine: A Phase 3 Randomized Study.Neurology. 2018 Dec 11;91(24):e2222-e2232.
Bernice Kuca, Stephen D Silberstein, Linda Wietecha.Lasmiditan Is an Effective Acute treatment, for Migraine: A Phase 3 Randomized Study.Neurology. 2018 Dec 11;91(24):e2222-e2232.

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Product Notes

The Lasmiditan hydrochloride (Catalog #AAA5759202) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Lasmiditan hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Lasmiditan hydrochloride, Inhibitor