Structure
Lasmiditan succinate, Inhibitor
Lasmiditan succinate
Purity
98.00%
Synonyms
Lasmiditan succinate; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C42H42F6N6O8
SMILES
OC(=O)CCC(O)=O.CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2c(F)cc(F)cc2F)n1.CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2c(F)cc(F)cc2F)n1
CAS Number
439239-92-6
Target & IC50
5-HT(1F): ic50 2.21nM (Ki)
In Vitro
Lasmiditan, a novel serotonin1F receptor agonist, showed specific affinity in vitro for the receptor without any vasoconstrictive action and inhibited markers associated with electrical stimulation of trigeminal ganglion in migraine animal models[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for Lasmiditan succinate, inhibitor
Lasmiditan succinate is a 5-ht (1F) receptor agonist acting on the central nervous system(Ki value of 2.21nM).
Product Categories/Family for Lasmiditan succinate, inhibitor
References
Capi M, de Andres, Fernando, Lionetto L, et al. Lasmiditan for the treatment,of migraine[J]. Expert Opinion on Investigational Drugs, 2017, 26(2):227-234.
Capi M, de Andres, Fernando, Lionetto L, et al. Lasmiditan for the treatment,of migraine[J]. Expert Opinion on Investigational Drugs, 2017, 26(2):227-234.
Kuca B, Silberstein S D, Wietecha L, et al. Lasmiditan is an effective acute treatment, for migraine: A phase 3 randomized study[J]. Neurology, 2018, 91(24):10.1212/WNL.0000000000006641.
Kuca B, Silberstein S D, Wietecha L, et al. Lasmiditan is an effective acute treatment, for migraine: A phase 3 randomized study[J]. Neurology, 2018, 91(24):10.1212/WNL.0000000000006641.
Capi M, de Andres, Fernando, Lionetto L, et al. Lasmiditan for the treatment,of migraine[J]. Expert Opinion on Investigational Drugs, 2017, 26(2):227-234.
Kuca B, Silberstein S D, Wietecha L, et al. Lasmiditan is an effective acute treatment, for migraine: A phase 3 randomized study[J]. Neurology, 2018, 91(24):10.1212/WNL.0000000000006641.
Kuca B, Silberstein S D, Wietecha L, et al. Lasmiditan is an effective acute treatment, for migraine: A phase 3 randomized study[J]. Neurology, 2018, 91(24):10.1212/WNL.0000000000006641.
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Product Notes
The Lasmiditan succinate (Catalog #AAA5759215) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Lasmiditan succinate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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