Structure
Eltoprazine hydrochloride, Inhibitor
Eltoprazine hydrochloride
Purity
98.00%
Synonyms
Eltoprazine hydrochloride; DU 28853 hydrochloride; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
H2O: 28mg/mL (109.06mM)
DMSO: 31mg/mL (120.75mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
DMSO: 31mg/mL (120.75mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C12H17ClN2O2
SMILES
Cl.c1cc2c(c(N3CCNCC3)c1)OCCO2
CAS Number
98206-09-8
Target & IC50
5-HT1A: ic50 40nM
5-HT1B: ic50 52nM
5-HT2B: ic50 81nM
5-HT
5-HT1B: ic50 52nM
5-HT2B: ic50 81nM
5-HT
In Vitro
Eltoprazine hydrochloride exerts a dose-dependent decrease in aggressive behavior in resident-intruder tests with rats (ID50 = 0.24mg/kg)[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for Eltoprazine hydrochloride, inhibitor
Eltoprazine hydrochloride is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81nM, respectively).
Product Categories/Family for Eltoprazine hydrochloride, inhibitor
References
Boer S F D, Lesourd M, Mocaer E, et al. Selective Antiaggressive Effects of Alnespirone in Resident-Intruder Test Are Mediated via 5-Hydroxytryptamine1A Receptors: A Comparative Pharmacological Study with 8-Hydroxy-2-Dipropylaminotetralin, Ipsapirone, Buspirone, Eltoprazine, and WAY-100635[J]. Journal of Pharmacology & Experimental Therapeutics, 1999, 288(3):1125-1133.
Gravius A, Dekundy A, Vanaga A, et al. Further pharmacological characterization of eltoprazine: Focus on its anxiolytic, anorexic, and adverse-effect potential[J]. Acta neurobiologiae experimentalis, 2017, 77(1):77-85.
Gravius A, Dekundy A, Vanaga A, et al. Further pharmacological characterization of eltoprazine: Focus on its anxiolytic, anorexic, and adverse-effect potential[J]. Acta neurobiologiae experimentalis, 2017, 77(1):77-85.
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Product Notes
The Eltoprazine hydrochloride (Catalog #AAA5758393) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Eltoprazine hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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