Structure
HS-38, Inhibitor
HS-38
Purity
>98% (HPLC)
Synonyms
HS-38; HS38; inhibitor
Purity/Purification
>98% (HPLC)
Target
DAPK
Receptor
DAPK
Chemical Name
2-[[1-(3-Chlorophenyl)-4, 5-dihydro-4-oxo-1H-pyrazolo[3, 4-d]pyrimidin-6-yl]thio]propanamide
SMILES
CC(SC1=NC(N(C2=CC=CC(Cl)=C2)N=C3)=C3C(N1)=O)C(N)=O
Molecular Formula
C14H12ClN5O2S
CAS Number
1030203-81-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for HS-38, inhibitor
HS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200nM for DAPK1 and Kd of 280nM for ZIPK, also inhibits Pim3 (IC50=200nM), and displays no activity against Src or Abl, little activity against EGFR; decreases RLC20 phosphorylation in cells, and decreases contractile force generated in mouse aorta, rabbit ileum, and calyculin A stimulated arterial muscle by decreasing RLC20 and MYPT1 phosphorylation; also promotes relaxation in Ca (2+)-sensitized vessels.
Product Categories/Family for HS-38, inhibitor
References
1. Carlson DA, et al. ACS Chem Biol. 2013 Dec 20; 8 (12):2715-23.
2. MacDonald JA, et al. Mol Pharmacol. 2016 Jan; 89 (1):105-17.
2. MacDonald JA, et al. Mol Pharmacol. 2016 Jan; 89 (1):105-17.
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Product Notes
The HS-38 (Catalog #AAA3600146) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HS-38, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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