Testing Data
Flavopiridol HCl, Inhibitor
Flavopiridol HCl
Purity
>98% (HPLC); NMR (Conforms)
Synonyms
Flavopiridol HCl; 2-(2-Chlorophenyl)-5; 7-dihydroxy-8-[(3S; 4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one; hydrochloride; L 86-8275; Alvocidib; NSC-649890; inhibitor
Purity/Purification
>98% (HPLC); NMR (Conforms)
Specific Activity
CDK Inhibitor
CAS Registry Number
131740-09-5
Molecular Formula
C21H20ClNO5-HCl
Preparation and Storage
Store desiccated as supplied at -20 degree C for up to 2 years. Store solutions at -20 degree C for up to 1 month.
Testing Data
Testing Data
Related Product Information for Flavopiridol HCl, inhibitor
Cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase (1). Potentiates (100-200 nM) PMA-induced apoptosis in HL-60 and U937 cells (2). Potentiates the effects of topoisomerase I inhibitors by suppressing Rad51 expression in a p53-dependent manner. Displays potent antiviral activity against HIV-1 and HSV-1 in vitro (4).
Product Categories/Family for Flavopiridol HCl, inhibitor
References
1. Kaur G et al. J. Natl. Cancer Inst. 1992 84:1736 2. Cartee L et al. Mol. Pharmacol. 2002 61:1313 3. Ambrosini G et al. Cancer Res. 2008 68:2312 4. Schang LM et al. Biochim. Biophys. Acta 2004 1697:197
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Product Notes
The Flavopiridol HCl (Catalog #AAA516358) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Flavopiridol HCl, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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